The researchers of the first study that uses data of the Personalized Parkinson Project are making great progress. They have collected baseline data in 347 Parkinson patients (ON medication) and 60 healthy controls. For 29 patients they have also performed additional measurements OFF medication. They are proud to present their initial findings and plans for the future.
- Study 1 (n=325 Parkinson patients ON dopaminergic medication, baseline versus follow-up of 2 years)
- Study 2 (n=50 Parkinson patients OFF dopaminergic medication; n=50 healthy controls, baseline versus follow-up of 2 year)
The researchers have collected baseline data (fMRI and clinical) in 347 Parkinson patients (ON medication) and 60 healthy controls. Furthermore, in 29/347 patients, they have also performed additional measurements OFF medication. Patients are able to adequately perform the task with few errors; exclusion rates are very low (<10%). The first fMRI data analyses show that Parkinson patients have slower reaction times during response selection, and this is associated with reduced brain activity in the putamen. In the next years, the research team will collect follow-up data (fMRI and clinical) in both Parkinson patients and in healthy controls. This will allow them to test for changes in brain activity that are associated with disease progression.
Patients are highly motivated to participate in this study. The researchers have included 100% of subjects in study 1 and 75% of subjects in study 2. Patients are able to adequately perform the task. The quality of the fMRl scans is high, and exclusion rates are low (<10%). Initial analyses indicate clear differences between Parkinson patients and healthy controls. During the motor task, patients have significantly slower reaction times than healthy controls (for all conditions), and patients show significantly reduced task-related brain activity in the putamen contralateral to the movement. These findings are as expected. These initial findings form a strong basis for subsequent testing of longitudinal changes in motor-related brain activity when the follow-up data becomes available.
Difference in putamen activity for the internal 3 condition
Plans for the future
The project is on schedule. ln the next 2 years and 3 months, the research team will:
- Collect 31 more datasets (Parkinson patients OFF dopaminergic medication).
- Perform follow-up scans in all 347 Parkinson patients (ON medication) and in all 60 healthy controls after 2 years.
- Improve the data analysis pipeline (e.g. incorporate EMG data when analyzing the fMRl data).
- Link the clinical data to the fMRl data when the PEP environment is completed. This will allow them to test for relationships between individual disease characteristics (e.g. severity) and brain activity.
- Write scientific manuscripts on the findings, and present at international conferences.
- Furthermore, it is their aim to obtain funding to follow this unique cohort of Parkinson patients for a longer period than 2 years, ideally with both clinical and fMRl measurements.
Want to know more about these subjects? Click on the buttons below for more news.
Related news items
PPP Update An update on the progress and results so far, news about the study, and a prognosis9 October 2019
An update on the progress and results so far, a prognosis, and news about the study. From now on we will share an update every six months.read more
Long-term adherence with wearing a multi-sensor watch Poster presentation International Congress of Parkinson's Disease and Movement Disorders 201930 September 2019
We presented a poster on long-term adherence with wearing a multi-sensor watch at the latest International Congress of Parkinson's Disease and Movement Disorders in Nice, France (September 22-26, 2019).read more
Cycling for Parkinson's Personalized Parkinson Project team collects 500 euro for 'BikevoorParkinson'9 September 2019
On September 7th five members of the Personalized Parkinson Project team cycled for 'BikevoorParkinson': the yearly cycling event from partner ParkinsonNet.read more
Interview with Verily About their role and goal in the Personalized Parkinson Project and the Verily Study Watch28 June 2019
An interview with Verily Life Sciences for participants about their role and goal in the Personalized Parkinson Project and the Verily Study Watch.read more
New add-on study In May a new add-on study started on audible bradykinesia28 May 2019
In May a new add-on study of the Personalized Parkinson Project started. The researchers try to find a way to detect bradykinesia faster and better based on sound.read more
325 participants! Today we have proudly welcomed the 325th participant6 May 2019
Today we have proudly welcomed the 325th participant. We aim for a total of 650 participants, so we are half way there!read more